Our mission

The mission of the Center for High Throughput Organic Synthesis at Palacky University is to design and develop novel efficient syntheses of drug-like organic compounds and apply the synthetic routes for preparation of chemical libraries comprising tens to thousands compounds. The core research activity is focused on High Throughput Organic Synthesis (HTOS), an efficient and expeditious methodology for preparation of larger number of compounds. The chemical libraries are being developed for evaluation of their biological activity with use of High Throughput Screening (HTS). Synthesized compounds are tested for their biological activities by a battery of tests at cooperating laboratories including the Faculty of Medicine and Dentistry at Palacky University Olomouc (anticancer and antimicrobial activities), Dupont (USA), National Cancer Institute (USA) and National Institute of Health (USA).
In addition, the center is involved in the development of new polymeric materials applicable in tissue engineering in collaboration with Institute of Experimental Medicine, Academy of Science (CR).
Project leaders are engaged in international collaboration with foreign institutions including the Institute of Pharmacology, University of Tromsoe in Norway; Department of Physics and Chemistry, University of Odense in Denmark; RIKEN Advanced Science Institute in Japan; Swiss Tropical Institute in Basel. Broad collaboration has been established with the University of Notre Dame, USA. The PI of the Center has a joint position at the Department of Chemistry and Biochemistry of Notre Dame.

The research of the team scientists was awarded by several national as well as international grants, aimed at development of biologically active compounds with various applications.

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Synthesis of 1,000 compounds on Domino Block
synthesizer using the necklace coding strategy

Significant grants awarded in last five years

Modulation of signalling and regulatory pathways in normal and cancer cells
MSM6198959216 (2005-2011); sponsor: Ministry of education, youth and sports, CR

Biomedicine for regional development and human resources.
CZ.1.05/2.1.00/01.0030 (2010-2014); sponsor: European Union funds

Research of new compounds with anticancer activity with use of combinatorial chemistry
ME09057 (2009-2012); sponsor: Ministry of education, youth and sports, CR

Combinatorial chemistry in research and education
CZ.1.07/2.3.00/20.0009 (2011-2013); sponsor: European Union funds

Research of new compounds as potential drugs against childhood cancers
A/CZ0046/1/0022 (2008-2010); sponsor: EEA grants/Norway grants